Association study of genetic variants in TCF7L2 and ADIPOQ genes with diabetes, obesity and longevity in an elderly cohort from São Paulo

Name: Lais de Lima Bride
Type: PhD thesis
Publication date: 11/08/2021
Advisor:

Namesort descending Role
Flavia de Paula (M/D) Advisor *
Flavia Imbroisi Valle Errera Co-advisor *

Examining board:

Namesort descending Role
Carlos Magno da Costa Maranduba External Examiner *
Flavia de Paula (M/D) Advisor *
Flavia Imbroisi Valle Errera Co advisor *
Greiciane Gaburro Paneto Internal Examiner *
Marcelo Rizzatti Luizon External Examiner *
Teodiano Freire Bastos Filho Internal Examiner *

Summary: BRIDE, L.L. Association study of genetic variants in TCF7L2 and ADIPOQ genes with diabetes, obesity and longevity in an elderly cohort from São Paulo. 2021. 134p. Thesis (Doctoral in Biotechnology) - Postgraduation Biotechnological Programme, UFES, Espírito Santo. Brazil.
Type 2 diabetes mellitus (DM2) and obesity are complex diseases directly related to the quality and expectancy of life of elderly across the world in the current century. There are several reports that genetic factors play a crucial role in the risk for complex diseases. Therefore, the investigation of genetic biomarkers is an important biotechnological tool for the prevention and treatment of complex diseases, also for better healthy aging and lifespan. The TCFL72 and ADIPOQ genes encode important proteins participating in metabolic processes and these genes have been widely described by association studies. Thus, the main objectives of this study were to evaluate the association of the rs7903146 polymorphism in TCF7L2 gene with DM2 and obesity, as also the relation of the SNPs rs17300539 (-11391G/A), rs266729 (- 11377G/C), rs2241766 (+45T/G) and rs1501299 (+276 G/T) in ADIPOQ gene with longevity status. More than 1,000 participants from an elderly cohort named SABE (Saúde, Bem Estar e Envelhecimento - Health, Welfare and Aging) were evaluated over 10 years (2000 to 2010) and the anthropometric, clinical and genetic data were collected during this period. The TCF7L2 and ADIPOQ genotypes were extracted from the ABraOM (Online Archive of Brazilian Mutations) database. Logistic regression models and additional statistical analysis were performed and the main findings were: the association of TCF7L2 rs7903146 T allele with the risk for DM2 in inverse relation to the BMI status; the TCF7L2 rs7903146 C allele increased the risk for obesity; Association of the ADIPOQ variants rs2241766 with longevity and rs1501299 with protection for longevity; The “T/T” haplotype from rs2241766 and rs1501299 variants showed association with less chance for longevity, WHEREas the “G/G” haplotype from the same variants was positively associated with longevity risk. When gender was considered, we detected stronger associations of rs7903146 SNP with diabetes in men, while more significant values concerning the association of ADIPOQ variants with longevity were observed in women. Thus, the present study confirms the TCF7L2 rs7903146 SNP association with diabetes and obesity and that ADIPOQ variants are associated with longevity status in our studied cohort.
Keywords: polymorphisms, genes, diabetes, obesity, longevity, elderly;

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