ANTIOXIDANT EFFECTS OF ROSMARIN ACID IN THE RENIN ANGIOTENSIN SYSTEM IN THE PARKINSON EXPERIMENTAL MODEL
Name: JOÃO MARCOS LIRA DE MÉLO
Publication date: 18/05/2018
Advisor:
Name |
Role |
|---|---|
| SONIA ALVES GOUVEA | Advisor * |
Examining board:
| Name |
Role |
|---|---|
| BRENO VALENTIM NOGUEIRA | Internal Examiner * |
| MARCELO PERIM BALDO | External Examiner * |
| SONIA ALVES GOUVEA | Advisor * |
Summary: Rosmarinic acid (RA) is the chemical component of plants widely used in the medicinal environment, such as rosemary, sage, among others. Its antioxidant capacity is studied as a natural alternative route for the treatment of several diseases, but its effect on the renin angiotensin system (RAS) in the nervous central system model of Parkinson's is still little known.The objective of this study was to investigate the influence of AR on the SRA of C57bl / 6 mice affected by the MPTP toxin in the brainstem. The animals were treated with the MPTP toxin (30 mg / kg) for induction of Parkinson's disease, one group receiving the toxin and the other in addition to MPTP, RA was given at a dose of 20 mg / kg orally for 14 days. Control animals were divided into a CON group, another group received only RA at a dose of 20 mg / kg (AR group). The evaluation of the weight of the organs of the animals showed a significant alteration in liver weight and histomorphometric changes in the kidneys. Protein expression of antioxidant proteins (SOD and catalase) did not show significant differences between groups. No differences were observed between groups in ECA1 expression. However, there was a significant reduction in the AT2 receptor of the MPTP group in relation to the control group, a significant increase of AT2 receptor in MPTP/AR was also seen. These results show a protective and regulatory effect of RA on RAS. Thus, the results show that rosmarinic acid may be a promising pathway for the search of new means of treatments for diseases that alter the renin angiotensin system
