INFLUENCE OF POLYMORPHOSMS OF GCK, TCF7L2 AND LEPR GENES IN BABY WEIGHT: A CLINICAL AND MOLECULAR CORRELATION
Name: LYVIA NEVES REBELLO ALVES
Publication date: 20/04/2017
Advisor:
Name |
Role |
|---|---|
| IURI DRUMOND LOURO (M/D) | Advisor * |
Examining board:
| Name |
Role |
|---|---|
| DEBORA DUMMER MEIRA | Internal Examiner * |
| IURI DRUMOND LOURO (M/D) | Advisor * |
Summary: Birth weight is the main cause of neonatal mortality and morbidity and has long been used as an important public health indicator. Furthermore, birth weight can have long-term health consequences once it is closely related to the development of chronic diseases in adult life. Due to the significant role of maternal glucose concentration as a determinant factor of offspring birth weight, genes that alter glucose homeostasis are good candidates for genes that influences fetal growth, and thus birth weight. To evaluate the influence of maternal genetic variants in the offspring birth weight, three polymorphisms related to glucose metabolism were analyzed (GCK rs1799884, TCF7L2 rs7903146 e LEPR rs1137101) in 250 pregnant women who participates of a prospective cohort of Santo Antônio de Jesus BA, Brazil, through the utilization of TaqMan® assays and the Polimerase Chain Reaction (PCR) Real Time technic. Samples genotypes were correlated with obstetrical results and clinical, anthropometrics and life habits data of the mother. No significant direct association was found between maternal polimorphisms and the offspring birth weight. This result may be due to sample particularities, especially in relation to ethnicity, since 84% of the analyzed samples are black or brown. It was possible to verify a significant association (p<0.05) between the birth weight and the variables sex, maternal BMI and gestational age for all the three polymorphisms. Moreover, associations among the LEPR rs1137101 maternal genotypes with gestational age (p=0.037) and drinking alcohol (p=0.04) were found. These results suggest that other factors, whether environmental or genetic, are more related with offspring birth weight than maternal genetic variants that are associated with the glucose metabolism.
